ASSESSMENT OF CYTOTOXIC AND ANTICANCER ACTIVITY OF Zygophyllum album AND Suaeda palastina EXTRACTS ON HUMAN LIVER CANCER CELL LINES

El-Attar, Marwa M.; Awad, A. A.; Abdel-Tawab, F. M.; Kamel, H. A.; Ahmad, S. Ahmad; Hassan, Amal I.

doi:10.21608/ajs.2019.43663

ASSESSMENT OF CYTOTOXIC AND ANTICANCER ACTIVITY OF Zygophyllum album AND Suaeda palastina EXTRACTS ON HUMAN LIVER CANCER CELL LINES

Document Type : Original Article

Authors

¹ Radioisotopes Dept., Atomic Energy Authority, Egypt

² Genetics Dept., Fac. of Agric., Ain Shams Univ., P.O. Box 68, Hadayek Shubra 11241,Cairo, Egypt

³ Cell Biology Dept., National Research Centre, Dokki, Giza, Egypt

10.21608/ajs.2019.43663

Abstract

In this study, anticancer activity of Zygophyllum album and Suaeda palastina extracts was evaluated. Dichloromethane, methanol and hot water were used as solvents for extraction. Results indicated that the highest half-maximal inhibitory concentration (IC50) on human lung carcinoma (A549) cell lines was achieved by dichloromethane extracts of Z. album and S. palastina (70.48 μg/ml and 34.82 μg/ml respectively) compared to methanolic and hot water extracts. Furthermore, dichloromethane extracts of both plants had antiproliferative effect and highly cytotoxicity on human cancer cells. IC50 of Z. album was 27.74 μg/ml in the human hepatocellular carcinoma (HepG2), while IC50 of S. palaestina was 30.76 μg/ml with no cytotoxic activity on normal cell lines. In conclusion, these results suggest that Z. album and S. palaestina could be a good candidate species as a natural source of anticancer agents.

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