Document Type : Original Article
Authors
1
Dairy Science and Technology, Agriculture, Ain Shams University,Cairo,Egypt
2
Dairy Science and Technology, Agriculture, Ain Shams University,Cairo, Egypt.
3
Food Science and Technology Dept, Faculty of Agriculture, Ain Shams University
4
Dairy Production and Technology Unit, Dept. of Animal Breeding, Desert Research Center, Cairo, Egypt
5
Medicinal Food, National Organization for Drug Control and Research (NODCAR), Giza, Egypt
Abstract
The liver disease all over the world had a more attention towards the prevention methods; balanced diet can be effective and protective. Therefore, the objective of this study was to investigate the hepatoprotective role for dandelion leaves aqueous extract (prebiotic), camel milk, fermented camel milk (probiotic product), fermented camel milk fortified with dandelion leaves aqueous extract (Synbiotic product), camel casein and camel whey protein against carbon tetrachloride (CCl4) induced liver injury in rats. Rats were divided into eight groups (eight rats each). Group one was served as normal control (NC), while the other seven groups were injected intraperitoneal in beginning of experimental with single dose from carbon tetrachloride (CCl4). Animals from group three to seven received orally camel milk; dandelion leaves aqueous extract; fermented camel milk (probiotic product); Synbiotic product and whey camel milk; while, group eight received basal diets in which protein was replaced with 20% camel casein for 45 days. The results indicated that all previous materials exhibited scavenging activity; liver injury control group revealed increased in liver function (AST, ALT and ALP) and malondialdehyde (MDA) levels; whereas, decreased body weight gain, albumin and glutathione reduced (GSH) levels. Also, histological examination of hepatic showed more alteration due to carbon tetrachloride (CCl4) induced hepatocellular damage. While, treatment by dandelion aqueous extract(prebiotic), camel milk; fermented camel milk (probiotic product); fermented camel milk fortified with dandelion leaves aqueous extract (Synbiotic product), camel casein and camel whey protein resulted in a significant improvement in weight gain, liver function and oxidative stress parameters; also, suppresses the alteration in liver histology. It could be concluded that dandelion leaves aqueous extract (prebiotic), camel milk; fermented camel milk (probiotic product); fermented camel milk fortified with dandelion leaves aqueous extract (Synbiotic product), camel casein and camel whey protein should be used as ingredients in functional foods for hepatoprotective.
Keywords
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